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鼠单克隆抗体应用于临床的弊端是它具有免疫原性 ,可行的办法是将鼠单克隆抗体人源化。抗体人源化的过程已由鼠嵌合抗体发展到了转基因动物表达完全人抗体阶段 ,表达完全人抗体的转基因动物有鼠、牛等。文中介绍了这些转基因动物的构建特点及这两种动物表达的人单克隆抗体和人多隆抗体的应用意义
The shortcomings of the clinical application of murine monoclonal antibody is that it is immunogenic, it is feasible to humanize murine monoclonal antibody. The process of humanization of antibodies has been developed from murine chimeric antibodies to the stage of fully human antibody expression in transgenic animals, and transgenic mice expressing fully human antibodies include mice, cattle and the like. In this paper, the construction characteristics of these transgenic animals and the significance of their application in human and human