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目的：研究原发性肝癌ＣＤ４４ｖ的表达与其侵袭转移的关系。方法：应用ＲＴ－ＰＣＲ法及术后随访分析５４例原发性肝癌ＣＤ４４ｖｍＲＮＡ的表达情况及其与侵袭转移的关系。结果：９２．５９％的病例肝癌组织ｃＤ４４ｖｍＲＮＡ阳性表达，其中中－高度表达者占７７．７８％。在中－高度表达的病例中，肿瘤包膜的缺如、穿破，门静脉癌栓及瘤周卫星结节形成等侵袭转移相关指标明显高于阴性－微弱表达的病例（Ｐ＜０．００１）。随访回报４６例，ＣＤ４４ｖｍＲＮＡ中－高度表达者复发率（７７．１５％）明显高于阴性－微弱表达的病例（３６．３６％，Ｐ＜０．０２５），而前者生存率（２５．７１％）则明显较后者（７７．７８％）为低（Ｐ＜０．００５）。结论：原发性肝癌ＣＤ４４ｖｍＲＮＡ的表达能够反映肝癌的侵袭转移潜能。
Objective: To study the relationship between the expression of CD44v and the invasion and metastasis of primary liver cancer. Methods: The expression of CD44vmRNA in 54 cases of primary liver cancer and its relationship with invasion and metastasis were analyzed by RT-PCR and postoperative follow-up. RESULTS: The positive expression of cD44vmRNA was found in 92.59% of the cases, among which 77.78% were moderate-highly expressed. Among the moderately-highly-expressed cases, the tumor invasion and metastasis, portal vein tumor thrombosis, and formation of nodal nodular satellite nodules were significantly higher than the negative-weakly expressed cases (P<0.001). . Follow-up reports were performed in 46 patients. The recurrence rate of CD44v mRNA in high-expressing patients (77.15%) was significantly higher than that of negative-faintly expressed patients (36.36%, P<0.025), while the survival rate of the former (25.71%). ) was significantly lower than the latter (77.78%) (P < 0.005). Conclusion: The expression of CD44v mRNA in primary liver cancer can reflect the invasion and metastasis potential of liver cancer.