论文部分内容阅读
目的：了解美托洛尔对心室晚电位（ＶＬＰ）阳性病人的室性心律失常（ＶＡ）的影响，探讨高危ＶＡ的防治措施。方法：以体表信号叠加心电图（ＳＡ－ＥＣＧ）检测ＶＬＰ，结合动态心电图（ＤＣＧ）监测ＶＡ，８８例ＶＬＰ阳性的ＶＡ病人（男性５６例，女性３２例；年龄５５±ｓ７ａ）随机分为２组，Ａ组４６例服美托洛尔２５～５０ｍｇ，ｂｉｄ×４ｗｋ。Ｂ组４２例服安慰剂（维生素Ｃ）２００ｍｇ，ｔｉｄ×４ｗｋ，作为对照，ｗｋ４未复查２４ｈＤＣＧ及ＶＬＰ。结果：美托洛尔治疗后有３８例（８３％）ＶＡ获控制，有３９例（８５％）原ＶＬＰ阳性获转阴性，且无明显不良反应，５０～１００ｍｇ／ｄ时剂量与疗效之间无明显关系。对照组治疗后对ＶＡ的疗效为０，ＶＬＰ阳性者无１例转阴性。结论：美托洛尔能有效的控制ＶＬＰ阳性病人的ＶＡ。
Objective: To investigate the effect of metoprolol on ventricular arrhythmia (VA) in patients with ventricular late-potential (VLP) -positive patients and to explore the prevention and treatment measures of high-risk VA. Methods: VLP was detected by surface signal superposition electrocardiogram (SA-ECG), VA was monitored by dynamic electrocardiogram (DCG), 88 VLP-positive VA patients (56 males and 32 females; age 55 ± s7a) were randomly divided into 2 groups Group A, 46 patients served metoprolol 25 ~ 50mg, bid × 4wk. Group B 42 patients taking placebo (vitamin C) 200mg, tid × 4wk, as a control, wk4 did not review 24h DCG and VLP. RESULTS: Thirty-eight (83%) VA patients were controlled after metoprolol treatment, and 39 (85%) of the original VLPs were negative and negative. There was no significant adverse reaction. Between 50 and 100 mg / d dose and effect No obvious relationship. The control group after treatment for the efficacy of VA 0, VLP-positive, no negative in 1 case. Conclusion: Metoprolol can effectively control VA in VLP positive patients.