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目的探讨结直肠间质瘤的临床诊断、治疗和预后。方法回顾性分析中国人民解放军总医院1993年3月至2002年3月收治的14例结直肠间质瘤的临床、病理资料及随访结果。结果临床表现为消化道出血(7/14)、腹部不适(4/14)、腹部肿块(2/14),无症状1例。病变部位为结肠6例,直肠8例。14例均行手术治疗,诊断为良性2例,交界性1例,恶性11例。免疫组化CD117(+)92%(13/14),CD34(+)78%(11/14)。随访率71%,病人平均生存时间为56个月。结论低位直肠恶性间质瘤病人,宜经骶尾部或会阴部切口行直肠局部切除术。
Objective To investigate the clinical diagnosis, treatment and prognosis of colorectal stromal tumors. Methods The clinical, pathological data and follow-up results of 14 cases of colorectal stromal tumors admitted to PLA General Hospital from March 1993 to March 2002 were retrospectively analyzed. Results The clinical manifestations included gastrointestinal bleeding (7/14), abdominal discomfort (4/14), abdominal mass (2/14) and asymptomatic one case. Lesions in 6 cases of colon, rectum in 8 cases. All 14 cases underwent surgical treatment, 2 cases were diagnosed as benign, 1 case was borderline and 11 cases were malignant. Immunohistochemical CD117 (+) 92% (13/14), CD34 (+) 78% (11/14). Follow-up rate of 71%, the average survival time of patients was 56 months. Conclusions Patients with low rectal malignant stromal tumors should undergo resection of the rectum through the sacrococcygeal or perineal incision.