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目的:通过测定某厂接触氟工人尿氟和羟脯氨酸含量,比较测值的变化,以探讨随着吸氟时间的延长,氟对人体的骨骼损害程度及评价环保改善情况。方法:从1997年、1998年、1999年、2001年四年每年随机抽查生产车间接触氟作业工人,测定尿氟和羟脯氨酸含量。结果:1997年尿氟含量明显高于其它三年(P<0.01)。而其它每年之间比较无显著性差别(P>0.05);尿羟脯氨酸含量2001年最高,与1998年、1999年比较差异非常明显(P<0.01或<0.001)。结论:1998年以后尿氟显著降低,但仍处于较高水平的稳定状态,随着时间的延长,氟对机体骨骼的胶原蛋白损害有所增加。
OBJECTIVE: To determine the extent of fluoride damage to human bones and evaluate the environmental improvement by measuring the changes of urinary fluoride and hydroxyproline content in fluoride exposed workers. Methods: Fluoride and hydroxyproline contents were determined by random sampling workers in the production workshop from 1997 to 1998, 1999 and 2001 respectively. Results: The urinary fluoride content in 1997 was significantly higher than the other three years (P <0.01). (P> 0.05). The content of urinary hydroxyproline was the highest in 2001, which was significantly different from that in 1998 and 1999 (P <0.01 or <0.001). CONCLUSION: Urinary fluoride decreased significantly after 1998, but remained at a relatively high level of stability. As time went on, fluorine had an increased damage to the collagen of the body skeleton.