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BACKGROUND AND OBJECTIVE: To compare the influence of low- molecular- weight viscoelastics on postoperative intraocular pressure (IOP) and corneal endothelial cell loss after phacoemulsification surgery. PATIENTS AND METHODS: Sixty- nine eyes undergoing phacoemulsification surgery were randomized to have either Opegan (Santen Pharmaceuticals, Osaka, Japan) alone or the soft- shell technique using Viscoat (Alcon Surgical, Fort Worth, TX) during phacoemulsification. The IOP was measured preoperatively and at 5 and 24 hours postoperatively. Intraoperative factors and corneal endothelial cell loss were also examined. RESULTS: Mean IOP was increased at 5 hours after surgery but returned to preoperative levels at 24 hours in the Opegan group, whereas it remained higher at 24 hours than at preoperative levels in the soft- shell group. When comparing groups, IOP at 5 and 24 hours postoperatively in the Opegan group was significantly less than that in the soft- shell group. Corneal endothelial cell loss was approximately the same in the two groups. CONCLUSION: The increase in IOP following phacoemulsification surgery with the use of Opegan was less than that with the soft- shell technique using Viscoat, although endothelial injury was almost the same.
BACKGROUND AND OBJECTIVE: To compare the influence of low- molecular-weight viscoelastics on postoperative intraocular pressure (IOP) and corneal endothelial cell loss after phacoemulsification surgery. PATIENTS AND METHODS: Sixty-nine eyes undergoing phacoemulsification surgery were randomized to have either Opegan (Santen Pharmaceuticals, Osaka, Japan) alone or the soft-shell technique using Viscoat (Alcon Surgical, Fort Worth, TX) during phacoemulsification. The IOP was measured preoperatively and at 5 and 24 hours postoperatively. Intraoperative factors and corneal endothelial cell loss were also examined . RESULTS: Mean IOP was increased during 5 hours after surgery but returned to preoperative levels at 24 hours in the Operative group; and 24 hours postoperatively in the Opegan group was significantly less than that in the soft-shell group. Corneal endothelial CONCLUSION: The increase in IOP following phacoemulsification surgery with the use of Opegan was less than that with the soft-shell technique using Viscoat, although endothelial injury was almost the same.