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液体制剂的水解、溶剂化和分解不是一个新问题,常用的补救办法包括维持一个合理的pH值,仔细地选择缓冲系统、缓冲剂浓度和络合剂,选用一种低溶解型的药物,用表面活性剂,改变化学结构和用低介电常数溶剂部分或全部代替水。许多药物在溶液中稳定性的改变是由于溶剂本身性质的改变引起的。从化学动力学的观点看,介电常数是影响溶剂化反应速率的基本性质之一。本使用反相HPLC法研究溶剂组成对阿司帕坦(aspartame,N-α-L-天冬氨酰基
Hydrolysis, solvation and decomposition of liquid formulations are not a new problem. Common remedies include maintaining a reasonable pH, careful selection of buffer systems, buffer concentrations and complexing agents, selection of a less soluble drug, use of Surfactants, changing chemical structures and replacing some or all of the water with low dielectric constant solvents. The stability of many drugs in solution changes due to changes in the nature of the solvent itself. From the viewpoint of chemical kinetics, the dielectric constant is one of the basic properties that affects the rate of solvation reaction. The use of reversed-phase HPLC method to study the solvent composition of aspartame (N-α-L-aspartyl