肺表面活性物质分子层理论的研究进展

• 作 者: 孙雨 方凤
• 机 构: 第二军医大学附属长海医院儿科!上海200433,第二军医大学附属长海医院儿科!上海200433
• 出 处: 国外医学(生理、病理科学与临床分册)
• 发表日期: 2001年01期
• 关键词: 肺表面活性物质 分子层 聚体 转化

肺表面活性物质 (PS)最重要的功能是降低肺泡气液界面的表面张力。以前一直沿用单分子层理论解释PS如何降低表面张力 ,随着研究深入 ,发现许多现象不能用单分子层理论解释。近几年的研究结果提示 :①PS在气液界面形成的表面活性膜是由多层分子组成的 ;②表面活性膜极有可能呈液晶状态 ,当膜处于扩张状态时 ,主要表现为液态特征 ,而处于压缩状态时则具有晶体某些特征 ,其结构基础是PS大小聚体相互转化 ;③任何影响PS聚体转化因素皆可改变PS的表面活性。

The most important function of pulmonary surfactant (PS) is to reduce the surface tension of the alveolar gas-liquid interface. In the past, monolayer theory was used to explain how PS reduces surface tension. As the research progresses, many phenomena can not be explained by the monolayer theory. The research results in recent years suggest that: ① the surface active film formed by PS at the gas-liquid interface is composed of multiple layers of molecules; ② the surface active film is likely to be in the liquid crystal state. When the film is in an expanded state, While in the compressed state has some characteristics of the crystal, which is based on the structure of the PS macromolecules mutual transformation; ③ any impact on the PS-mer conversion factors can change the surface activity of PS.