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环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)等环磷核苷酸的发现及对其作用的阐明,是近来分子生物学的重大进展,为细胞学、遗传学、生物化学、内分泌以及临床医学开辟了崭新的研究领域。一、cAMP与cGMP的发现 1957年Sutherland等首先报道,研究肾上腺素和胰高血糖素在肝脏及肌肉里促进糖原分解的机制时发现了一种耐热因子,并证实它为cAMP。1958年他们详述了cAMP的一般特征。1963年Ashmam等发现尿中有自然存在的cGMP。二、环磷核苷酸的一般作用机理通过激素来控制物质代谢是高等动物体内代谢调
The discovery of cyclic phosphorus nucleotides such as cAMP and cGMP and their elucidation of their roles are major advances in recent molecular biology. They are cytology, genetics, biochemistry, endocrine As well as clinical medicine has opened up new areas of research. First, the discovery of cAMP and cGMP Sutherland et al. First reported in 1957, adrenaline and glucagon in the liver and muscle research to promote glycogenolysis mechanism found a heat-resistant factor, and confirmed that it is cAMP. In 1958 they detailed the general characteristics of cAMP. In 1963, Ashmam et al. Found that there is naturally occurring cGMP in the urine. Second, the general mechanism of action of cyclic phosphorus nucleotide Control of substance metabolism by hormones is higher metabolism in vivo animals tone