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目的:探讨口腔刺激联合母乳吮吸对先天性消化道畸形患儿PICC所致疼痛的应用价值。方法:采用便利抽样法，选取2018年7月至2019年12月湖南省儿童医院收治的80例先天性消化道畸形患儿，按照随机数字表法分为试验组和对照组各40例。对照组采用常规护理模式，试验组在常规护理基础上实施口腔刺激联合母乳吮吸干预。使用新生儿疼痛评估量表（NIPS）、首次啼哭开始时间、啼哭持续时间、首次疼痛面容开始时间、疼痛面容持续时间以及心率、呼吸频率和SpOn 2等指标评价干预效果。n 结果:穿刺期、恢复期：试验组患儿NIPS评分分别为（5.60 ± 1.24）、（4.10 ± 0.31）分，明显低于对照组的（6.10 ± 0.84）、（4.93 ± 0.35）分，差异有统计学意义（n t=2.12、3.00，均n P<0.05）；试验组患儿心率和呼吸频率分别为（151.10 ± 12.37）、（147.00 ± 12.16）次/min和（47.48 ± 7.59）、（45.58 ± 6.51）次/min，明显低于对照组的（159.75 ± 13.81）、（156.05 ± 12.99）次/min和（52.38 ± 8.12）、（49.75 ± 7.59）次/min，差异有统计学意义（n t值为2.64~3.22，均n P<0.05）；试验组SpOn 2为0.980 5 ± 0.009 0、0.982 5 ± 0.010 8，明显高于对照组的0.970 8 ± 0.014 2、0.971 8 ± 0.018 1，差异有统计学意义（n t=3.66、3.23，均n P<0.05）。试验组患儿首次啼哭开始时间、啼哭持续时间、首次疼痛面容开始时间、疼痛面容持续时间分别为（41.55 ± 6.38）、（22.05 ± 4.47）、（35.08 ± 5.94）、（24.65 ± 5.46）s，明显短于对照组的（46.58 ± 5.26）、（29.50 ± 6.48）、（44.68 ± 13.31）、（30.65 ± 9.42）s，差异有统计学意义（n t值为2.63~5.98，均n P<0.05）。n 结论:口腔刺激联合母乳吮吸可有效缓解先天性消化道畸形患儿PICC所致疼痛，减轻患儿生理应激反应。“,”Objective:To investigate the application value of oral stimulation combined with maternal milk sucking in the pain caused by PICC in children with congenital digestive tract malformations.Methods:Using convenience sampling method, 80 children with congenital digestive tract malformations who were admitted to Hunan Children\'s Hospital from July 2018 to December 2019 were selected and divided into the experimental group and the control group of 40 cases in each group according to the random number table method. The control group was given routine nursing mode, while the experimental group was given oral stimulation combined with maternal milk sucking intervention on the basis of routine nursing. The intervention effects were evaluated by the Neonatal Infant Pain Scale (NIPS), the onset time of the first cry, the duration of crying, the onset time of the first painful face, the duration of the painful face, and indicators such as heart rate, respiratory rate and SpOn 2.n Results:The NIPS scores of children in the experimental group were (5.60 ± 1.24) and (4.10 ± 0.31) in the puncture period and the recovery period, which were significantly lower than those in the control group (6.10 ± 0.84), (4.93 ± 0.35), the differences were statistically significant (t = 2.12, 3.00, both P<0.05). The heart rate and respiratory rate of the children in the experimental group were (151.10 ± 12.37), (147.00 ± 12.16) times/min and (47.48 ± 7.59), (45.58 ± 6.51) times/min in the puncture period and the recovery period, which were significantly lower than those in the control group (159.75 ± 13.81), (156.05 ± 12.99) times/min and (52.38 ± 8.12), (49.75 ± 7.59) times/min, the differences were statistically significant (t values were 2.64-3.22, all P<0.05). The SpOn 2 in the experimental group were 0.980 5 ± 0.009 0, 0.982 5 ± 0.010 8 in the puncture period and the recovery period, which were significantly higher than those in the control group 0.970 8 ± 0.014 2, 0.971 8 ± 0.018 1, the differences were statistically significant (t = 3.66, 3.23, both P<0.05). The onset time of the first cry, the duration of crying, the onset time of the first painful face, the duration of the painful face in the experimental group were (41.55 ± 6.38), (22.05 ± 4.47), (35.08 ± 5.94), (24.65 ± 5.46) s, significantly shorter than those in the control group (46.58 ± 5.26), (29.50 ± 6.48), (44.68 ± 13.31), (30.65 ± 9.42) s, the differences were statistically significant (t values were 2.63-5.98, all P<0.05).n Conclusions:Oral stimulation combined with maternal milk sucking can effectively relieve the pain caused by PICC in children with congenital digestive tract malformation, and reduce the physiological stress response of children.