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Background Recent studies indicate that Sl 00P expression may be a biomarker that can predict the success of cancer chemotherapy. Whether it is relevant to chemOtherapeutics in ovarian cancer is unknown.In this study,we investigated the association of S1OOP expression with paclitaxel sensitivity in ovarian cancer cell lines.Methods We measured S1 OOP expression and paclitaxel resistance profiles in parent SKOV3 and OVCAH3 cell lines.Then,the two cell lines were transiently transfected with SlOOP siRNA.We also constructed an OVCAR3 cell clone that stably overexpressed SIOOP The effect of S100P expression level on the survival of cells exposed to paclitaxel was measured using the MTT assav.S1OOP expression was evaluated by semi-quantitative RT.PCR and Western blotting.Significance of differences was calculated using independent samples t-test and one way analysis of variance(ANOVA).Results Lower S1 00P expression was associated with a survival advantage in OVCAR3 cells exposed to paclitaxel;the survival advantage in SKOV3 cells was smaller P