【摘 要】
：
研究幽门螺杆菌(Helicobacter pylori,Hp)感染促血管生成素2(angiopoietin2,Ang2)及其受体Tie2、CD34和HER-2/neu蛋白的表达的影响,以探讨Hp诱导胃癌发生发展的可能机制,并寻
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研究幽门螺杆菌(Helicobacter pylori,Hp)感染促血管生成素2(angiopoietin2,Ang2)及其受体Tie2、CD34和HER-2/neu蛋白的表达的影响,以探讨Hp诱导胃癌发生发展的可能机制,并寻找胃癌可能的肿瘤标记物。胃癌病人Hp阳性13例,阴性16例,取病灶组织,应用免疫组化方法检测Ang-2、Tie2、CD34和HER-2/neu蛋白的表达。同时将产幽门螺杆菌毒力因子(cytotoxin-associated gene A,cagA)的Hp培养滤液加入胃癌细胞(MGC-803)及正常胃粘膜上皮细胞(GES-1)的培养基中,48 h后应用流式细胞仪检测Tie2、HER-2/neu蛋白的表达。免疫组化结果显示与Hp阴性胃癌组相比,Hp阳性组Ang2和Tie2的阳性表达率均显著升高;流式检测结果显示:幽门螺杆菌毒力因子的添加导致MGC-803细胞中HER-2/Neu的表达显著增加(P<0.05),而正常胃粘膜GES-1细胞Neu表达无明显变化。上述结果表明Ang2及其受体Tie2参与了Hp诱导的胃癌发生发展,对两者的检测可能预示胃癌的发生,含CagA蛋白的幽门螺杆菌培养滤液单独作用能够增强HER-2/Neu的表达。
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