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目的为了研究细胞外基质层粘连蛋白(LN)与肌腱蛋白(TN)在正常子宫内膜及子宫内膜异位症(内异症)异位内膜上的表达,探讨两者与内异症发生的关系。方法应用免疫组化方法分别检测正常子宫内膜及内异症异位内膜病理蜡块标本LN及TN表达水平。结果LN在内异症异位内膜和正常子宫内膜组织的基底膜及细胞外基质(ECM)中表达差异不显著;TN在内异症异位内膜和正常子宫内膜组织的腺上皮及ECM中表达差异有显著性。结论LN的表达与内异症的发生无关,不能作为内异症的一种预测指标。TN在内异症异位内膜及正常子宫内膜中的细胞外基质中表达差异显著,对内异症的发生可能起重要作用。
Objective To investigate the expression of extracellular matrix laminin (LN) and tenascin (TN) on ectopic endometrium of normal endometrium and endometriosis (endometriosis) and to explore the relationship between them and endometriosis What happened? Methods Immunohistochemical methods were used to detect the expression of LN and TN in eutopic and ectopic endometrial lesions of normal endometrium and endometriosis, respectively. Results There was no significant difference in the expression of LN in the basement membrane and extracellular matrix (ECM) between ectopic and eutopic endometrium of endometriosis. The expression of LN in endometriotic ectopic endometrium and normal endometrial epithelium And ECM expression differences were significant. Conclusion The expression of LN has nothing to do with the occurrence of endometriosis, can not be used as a predictor of endometriosis. The expression of TN in the extracellular matrix of ectopic endometrium and normal endometrium is significantly different, which may play an important role in the occurrence of endometriosis.