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目的探讨急性冠脉综合征患者急诊PCI术前后妊娠相关蛋白A、高敏C反应蛋白水平的变化意义及与冠脉病变程度的相关性。方法观察47例急性冠脉综合征患者术前1h及术后24hhs-CRP、PAPP-A水平变化,PCI术中冠脉造影确定冠状动脉病变血管数目,分析PCI对hs-CRP、PAPP-A变化的影响及hs-CRP、PAPP-A与冠脉病变程度的相关性。结果47例急诊PCI手术均获得成功,PCI术后hs-CRP、PAPP-A水平明显高于术前(P<0.05),双支和3支病变患者hs-CRP、PAPP-A水平明显高于单支病变患者(P<0.05)。结论PCI可导致体内hs-CRP、PAPP-A表达增加,hs-CRP和PAPP-A水平与冠脉病变程度存在明显的相关性。
Objective To investigate the significance of changes of pregnancy-associated protein A and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome before and after PCI and their correlations with the degree of coronary artery disease. Methods The changes of hs-CRP and PAPP-A in patients with acute coronary syndrome (ACS) at 1 h and 24 h after operation were observed. The number of coronary artery lesions was determined by coronary angiography in PCI. The changes of hs-CRP and PAPP- And the correlation between hs-CRP, PAPP-A and coronary artery disease. Results 47 cases of emergency PCI were successful. The levels of hs-CRP and PAPP-A after PCI were significantly higher than those before operation (P <0.05). The levels of hs-CRP and PAPP-A were significantly higher in patients with double- Single-vessel disease patients (P <0.05). Conclusion PCI can lead to the increase of hs-CRP and PAPP-A in vivo, and the correlation between hs-CRP and PAPP-A and coronary artery disease.