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本文研究rt-PA对闭胸犬阻塞血栓、心梗范围和室壁运动的有利作用以及这种作用与治疗开始时间的关系,并比较气囊导管充盈阻塞之后减压再通与rt-PA溶栓疗法的优劣。成年杂种犬、雌雄不限,体重11～24kg,以苯巴比妥钠(25mg/kg)静脉麻醉。气管插管、人工呼吸器正压呼吸,持续心电监护。在静脉注射1000U肝素后,通过将铜线圈插入左冠状动脉前降支(第一斜角支远端)造成阻塞性血栓。在血栓阻塞形成后,74条犬随机
This study was to investigate the beneficial effects of rt-PA on clot thrombosis, myocardial infarct size, and wall motion in a closed chest dog and the relationship between this effect and the initiation of treatment. Comparisons of balloon catheter obstruction after decompression followed by rt-PA thrombolysis The pros and cons. Adult mongrel dogs, male or female, weighing 11 ~ 24kg, with phenobarbital sodium (25mg / kg) intravenous anesthesia. Tracheal intubation, respirator positive pressure breathing, continuous ECG monitoring. After intravenous injection of 1000 U heparin, obstructive thrombus was created by inserting a copper coil into the left anterior descending coronary artery (distal end of the first beak). After thrombus formation, 74 dogs were randomized