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目的研究大鼠单次及连续7d静脉注射和灌胃D-聚甘酯后的药代动力学。方法应用生物分析法检测大鼠血浆中D-聚甘酯的浓度,采用DAS2.1.1版软件计算药代动力学参数。结果在0.05～150mg·L~(-1)浓度范围内量效呈良好的线性关系(r=0.9991);回收率在94.72%～103.21%之间,日内和日间变异小于15%。单次及连续注射和口服D-聚甘酯后Zata为0.89,1.06.0.93,0.85 h~1和t_(1′2(?))为0.78.0.69.0.75.0.87h,口服生物利用度为3%～5%。结论口服生物利用度低,注射和口服两种给药方式的末端消除一致。连续给药与单次给药的药代动力学参数差异无统计学意义。
Objective To study the pharmacokinetics of single and continuous 7d intravenous injection of D-polyglycerol in rats. Methods The concentration of D-polyglycerol in rat plasma was determined by bioassay. Pharmacokinetic parameters were calculated by DAS version 2.1.1. The results showed a good linear relationship (r = 0.9991) within the range of 0.05-150 mg · L -1 (r = 0.9991). The recoveries ranged from 94.72% to 103.21%. The intra- and inter-day variability was less than 15%. Zata was 0.89, 1.06.0.93, 0.85 h ~ 1 and t_ (1’2 (?)) Were 0.78.0.69.0.75.0.87 h after single and continuous injections and oral D-polyglycerols. The oral bioavailability was 3% ~ 5%. Conclusions The oral bioavailability is low, and the two ends of injection and oral administration are eliminated consistently. There was no significant difference in pharmacokinetic parameters between continuous administration and single administration.