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目的：评价血清和腹水中CA19-9、CEA含量变化对消化系统恶性肿瘤的诊断价值。方法：CA19-9采用免疫放射法（RIMA）、CEA采用放射免疫法（RIA），检测192例消化系统恶性肿瘤手术前、后及126例正常人血清CA19-9、CEA的含量；并观察20例癌性腹水及28例良性腹水CA19-9、CEA的含量与变化。且对血清CA19-9、CEA单项与联检阳性率进行比较。结果：所测各种恶性肿瘤病人血清CA19-9、CEA的含量均显著高于正常对照组（P＜0.01），手术后患者血清CA19-9、CEA的水平显著低于手术前（P＜0.01）；术前、术后比较阳性率有显著性差异（P＜0.01），且联检较单检阳性率有明显提高（P＜0.05）；癌性腹水患者血清、腹水中CA19-9、CEA水平明显高于良性腹水患者（P＜0.01）。结论：联合检测血清和腹水中CA19-9、CEA在消化系统恶性肿瘤的辅助诊断、疗效观察及良恶性腹水的鉴别中均有一定的临床应用价值。
Objective: To evaluate the diagnostic value of CA19-9 and CEA in serum and ascites for malignant tumor of digestive system. METHODS: CA19-9 was detected by radioimmunoassay (RIAA) and CEA was performed by radioimmunoassay (RIA). The contents of CA19-9 and CEA in 192 patients with digestive system malignancy were measured before and after surgery. Cases of cancerous ascites and 28 cases of benign ascites CA19-9, CEA content and changes. The positive rates of serum CA19-9 and CEA in single and joint tests were compared. Results: The serum levels of CA19-9 and CEA in all malignant tumors were significantly higher than those in the normal control group (P<0.01). The serum levels of CA19-9 and CEA after surgery were significantly lower than those before surgery. P<0.01); The preoperative and postoperative postoperative positive rates were significantly different (P<0.01), and the combined rate was significantly higher than the single test positive rate (P<0.05); cancerous ascites patients’ serum, The levels of CA19-9 and CEA in ascites were significantly higher than those in benign ascites (P<0.01). Conclusion: Combined detection of serum and ascites CA19-9, CEA in the diagnosis of malignant tumors of the digestive system, efficacy observation and the identification of benign and malignant ascites have some clinical application value.