3,4-二羟基苯腈的合成

• 出 处: 今日农药
• 发表日期: 2011年11期
• 关键词: 二羟基苯 合成 农药中间体 感光材料 喹唑啉类 化合物 香兰素 抗癌药物 嘧啶类 羟基苯

3,4-二羟基苯腈用于合成含噻唑、2-噁唑啉、咪唑、三唑及苯甲嘧啶类结构的化合物,是重要的医药及农药中间体,尤其合成的喹唑啉类化合物是重要的抗癌药物,近年来,3,4-二羟基苯腈也开始应用于感光材料的合成,市场需求量不断增加。13,4-二羟基苯腈的合成方法文献报道较多,根据所用起始原料不同,主要有以下几种。

3,4-Dihydroxybenzonitrile is used to synthesize compounds containing thiazole, 2-oxazoline, imidazole, triazole and pyrimidine structure. It is an important pharmaceutical and pesticide intermediates, especially synthetic quinazoline compounds Is an important anticancer drug. In recent years, 3,4-dihydroxybenzonitrile has also started to be used in the synthesis of photosensitive materials, and the market demand is constantly increasing. Synthesis of 13,4-dihydroxybenzonitrile reported in the literature more, according to the different starting materials used, there are the following.