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应用免疫组化方法，采用抗绒毛膜促性腺激素（ＨＣＧ），胎盘泌乳素（ＨＰＬ）及妊娠特异性糖蛋白（ＳＰ１）抗体，观察了５９例葡萄胎和侵袭性葡萄胎中肿瘤性滋养细胞的增生、分布及激素表达情况，结果表明：葡萄胎主要表现滋养细胞的轻－中度增生，合体滋养细胞（ＳＴ）数量为主，其次是细胞滋养细胞（ＣＴ），较少中间型滋养细胞。而侵袭性葡萄胎主要表现中－重度增生，ＩＴ及ＳＴ增生显著，尤其是ＩＴ数量较葡萄胎显著增多（Ｐ＜０．０１）。侵袭性葡萄胎在ＨＰＬ和ＳＰ１的表达上均较葡萄胎明显增强，这可能与ＩＴ的显著增生有关。我们认为不同滋养细胞的增生、分布及激素表达水平的测定，在两种肿瘤的诊断、鉴别诊断及预后方面是有意义的。
Immunohistochemical method was used to detect the expression of tumor-associated trophoblastic cells in 59 cases of hydatidiform mole and invasive hydatidiform mole with anti-chorionic gonadotropin (HCG), placental prolactin (HPL) and pregnancy-specific glycoprotein (SP1) The results showed that hydatidiform mole mainly showed mild to moderate hyperplasia of trophoblast, the number of syncytiotrophoblasts (ST) was the most, followed by cytotrophoblast (CT), less intermediate trophoblast . However, invasive hydatidiform mole mainly showed moderate-severe hyperplasia, significant IT and ST hyperplasia, especially the number of IT was significantly higher than that of hydatidiform mole (P <0.01). Invasive hydatidiform mole in HPL and SP1 expression were significantly higher than hydatidiform mole, which may be related to the significant proliferation of IT. We believe that the determination of the proliferation, distribution and hormone expression of different trophoblasts is of significance in the diagnosis, differential diagnosis and prognosis of the two tumors.