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用聚合酶链反应(PCR)方法对260例乙肝病毒(HBV)感染者血清HBV DNA进行检测的结果显示:PCR方法HBV DNA的检出率在HBeAg阳性、PreS_2Ag阳性和PHSA-R阳性者分别为95.7％、98.3％和92.2％。在HBeAg和(或)Pre-S_2Ag阴性血清中,慢性迁延性肝炎(慢迁肝)和慢性活动性肝炎(慢活肝)患者PCR的检出率依次为:HBsAg阳性组(64.3％,84.6％)、抗HBc并抗HBs阳性组(22.2％,52.2％),单项抗HBc阳性组(25.0％。61.5％)。慢迁肝HBsAg阳性组的PCR检出率高于阴性组;而慢活肝,三组间的PCR检出率无明显差异。
The detection of serum HBV DNA in 260 cases of HBV infection by polymerase chain reaction (PCR) method showed that the detection rate of HBV DNA in PCR method was HBeAg positive, PreS_2Ag positive and PHSA-R positive were 95.7%, 98.3% and 92.2%. In HBeAg and / or Pre-S 2Ag negative sera, the detection rates of PCR in patients with chronic persistent hepatitis (slowly migrating liver) and chronic active hepatitis (slowly living liver) were HBsAg positive group (64.3%, 84.6% ), Anti-HBc and anti-HBs positive group (22.2%, 52.2%) and single anti-HBc positive group (25.0% .61.5%). The PCR detection rate of HBsAg positive group was higher than that of negative group, while there was no significant difference among the three groups.