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目的:探讨HIV感染合并宫颈癌/癌前病变的维吾尔族患者临床资料。方法:选取在新疆医科大学附属肿瘤医院诊治的28例HIV抗体阳性合并宫颈癌/癌前病变的维吾尔族患者为观察组,等距抽样选择同期在新疆医科大学附属肿瘤医院诊治的28例HIV抗体阴性宫颈癌/癌前病变的维吾尔族患者为对照组。调查、分析并比较两组患者的HPV感染情况、治疗效果、不良反应及并发症。结果:两组近期疗效及HPV感染治疗后6个月复查阳性者比较,差异无统计学意义(P>0.05)。两组HPV多重感染率、治疗期间的放射性直肠炎及膀胱炎发生率、HPV感染治疗后3个月复查阳性情况比较,差异均有统计学意义(P<0.05)。结论:HIV抗体阳性合并宫颈癌/癌前病变患者的近期疗效较好,但这部分患者细胞免疫功能低,易出现并发症及不良反应,因此在其治疗期间应给予免疫制剂、及时预防及处理并发症。同时应引起医院及医务工作者的重视,做到早发现、早诊断和早治疗,提高患者的生存质量,更应加强AIDS的防控措施,防止院内感染的发生,预防和控制医务人员职业暴露的发生。
Objective: To investigate the clinical data of Uygur patients with HIV infection and cervical cancer / precancerous lesions. Methods: Totally 28 Uygur patients with HIV-positive cervical cancer / precancerous lesions diagnosed and treated in Tumor Hospital of Xinjiang Medical University were selected as the observation group. Twenty-eight HIV patients were selected at the same time in the Tumor Hospital of Xinjiang Medical University Negative cervical cancer / precancerous lesions of Uighur patients as control group. Investigation, analysis and comparison of two groups of patients with HPV infection, treatment, adverse reactions and complications. Results: There was no significant difference between the two groups in the short-term curative effect and the positive rate of HPV infection 6 months after treatment (P> 0.05). Two groups of HPV multiple infection rates, radiation proctitis during treatment and cystitis incidence, HPV infection 3 months after treatment, the positive review, the differences were statistically significant (P <0.05). Conclusions: The recent curative effect of HIV antibody positive cervical cancer / precancerous lesions is better, but this part of patients with low cellular immune function, prone to complications and adverse reactions, it should be given during the treatment of immune agents, timely prevention and treatment complication. At the same time, it should arouse the attention of hospitals and medical workers, so that early detection, early diagnosis and early treatment can improve the patients’ quality of life. AIDS prevention and control measures should be strengthened to prevent nosocomial infections and prevent and control occupational exposure of medical staff happened.