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22例长期肺结核患者服用大剂量异菸肼及盐酸吡多醇(维生素B_6)6至12个月。全部病例痰菌检查均阴性,曾用链霉素、对氨柳酸与异菸肼,有的曾用紫霉素、(?)丝氨酸与Cyancethydrazide治疗,其中14例经治疗5至10年。全部病例对链霉素已产生抗药性,只有三例病菌在大剂量治疗前对异菸肼敏感。所有病例的日剂量是每公斤体重20毫克异菸肼加1毫克吡多醇,分四次服,同时续用链霉素与对氨柳酸。开始服药时都发生毒性作用,手指与足趾有短短的刺痛与麻木,眩晕与头部发輕感,妇女常诉失眠,而男子诉用镇静感,这些副作用在几天內渐清退。一个67岁的病人异菸肼每公斤体重40毫克,三个月后发生周围神经系统疾病,停药即注射维生素B_6后即消
Twenty-two patients with long-term pulmonary tuberculosis received high-dose isoniazid and pyridoxine hydrochloride (vitamin B_6) for 6 to 12 months. All cases of sputum examination were negative, had used streptomycin, salicylic acid and isoniazid, and some had used viomycin, (?) Serine and Cyancethydrazide treatment, of which 14 cases were treated for 5 to 10 years. Streptomycin has been produced in all cases resistant, only three cases of bacteria sensitive to isoniazid before high-dose treatment. The daily dose for all cases was 20 mg of isoniazid plus 1 mg of pyridoxine per kg of body weight in 4 servings, with the addition of streptomycin and para-salicylic acid. Toxicity occurs when taking medication, fingers and toes have a short sting and numbness, dizziness and head hair, women often vomit insomnia, and men vomiting with sedation, these side effects gradually cleared in a few days . A 67-year-old patient isoniazid 40 mg per kilogram of body weight, peripheral nervous system disease after three months, withdrawal after injection of vitamin B_6