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目的:观察复方柴胡胶囊抗甲I型流感病毒的作用。方法:以甲I型病毒滴鼻感染小鼠,观察复方柴胡胶囊对小鼠肺指数、病毒致小鼠死亡率及肺部病理切片的影响。结果:复方柴胡胶囊0.5、1.0、2.0g/kg三个剂量组均可明显延长感染甲I型流感病毒小鼠的存活期,其中高剂量组可有效降低感染小鼠的肺指数,对肺组织的病变有一定的保护作用。结论:复方柴胡胶囊可改善流感病毒引起的小鼠肺炎症状,延长生命率,降低甲I型流感病毒感染小鼠的死亡率,对病毒性感冒有较好的疗效。
Objective: To observe the anti-influenza A virus effect of Fufang Chaihu Capsule. METHODS: Mice were infected intranasally with type I virus to observe the effects of Fufang Chaihu capsule on lung index, virus-induced mouse mortality, and pathological section of lung. Results: The three doses of Compound Chaihu Capsules 0.5, 1.0, and 2.0g/kg could significantly prolong the survival of mice infected with type I influenza virus. High-dose group can effectively reduce the lung index of infected mice. Tissue lesions have a protective effect. Conclusion: Compound Chaihu capsule can improve the symptoms of pneumonia caused by influenza virus, prolong the life rate, reduce the mortality of mice infected with influenza A virus, and has good curative effect on viral influenza.