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树突状细胞(dendritic cell,DC)由美国学者Steinman于1973年在小鼠脾脏中发现,因其成熟时能伸出许多树突样或伪足样突起而得名[1]。树突状细胞是目前所知的功能最强大的抗原提呈细胞(antigen presenting cell,APC),可摄取、加工抗原,激活初始T淋巴细胞,激发抗原特异性的免疫应答及免疫耐受[2],在固有免疫及获得性免疫中起着重要作用。树突状细胞与过敏性疾病发生密切相关,参与过敏反应发生的始动环节,因此,其在过敏性疾病中的研究应用已受到人们广泛关注。现主要从树突状细胞在过敏反应中的作用及其应用等方面进行综述。
Dendritic cells (DCs) were discovered in the spleen of mice by American scholar Steinman in 1973. They are named after they protrude into many dendritic or pseudopodlike protuberances when they mature [1]. Dendritic cells are currently the most powerful antigen presenting cells (APCs) that can ingest and process antigens, activate naive T lymphocytes, stimulate antigen-specific immune responses and immune tolerance [ 2], plays an important role in innate immunity and adaptive immunity. Dendritic cells are closely related to allergic diseases and participate in the initiation of allergic reactions. Therefore, their application in allergic diseases has drawn much attention. Now mainly from dendritic cells in the role of allergic reactions and its application and so on.