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目的研究骨质疏松母亲的女儿峰值骨量是否比正常母亲的女儿更低,并初步探讨导致这一差异的因素。方法从上海市各社区招募401个汉族核心家庭(包括父母双亲和一名20～40岁的健康女儿),用双能X线吸收仪测定腰椎(L1-4)和股骨近端各部位骨密度(BMD),剔除父亲患骨质疏松或骨量减少的家庭,获得126个骨质疏松母亲及其女儿和136个年龄匹配的BMD正常母亲及其女儿。结果骨质疏松母亲的女儿L1-4、股骨颈和大转子各部位BMD值(0.94g/cm2±0.10g/cm2,0.75g/cm2±0.10g/cm2,0.61g/cm2±0.08g/cm2,显著低于正常母亲的女儿(1.00g/cm2±0.11g/cm2,0.80g/cm2±0.11g/cm2,0.66g/cm2±0.09g/cm2,均P<0.001),且体重也显著低于正常母亲的女儿(P<0.05),两组间年龄、身高、月经初潮年龄、牛奶摄入者比例、摄入量等差异均无统计学意义。多因素逐步回归分析显示:体重是影响女儿各部位BMD的最重要因素,分别解释L1-4、股骨颈和大转子BMD值变异的9.4%、16.5%和16.6%。剔除体重因素后,母亲患骨质疏松成为影响女儿BMD的最重要因素,分别解释L1-4、股骨颈和大转子的BMD值变异的5.1%、5.3%和4.2%。结论母患骨质疏松的女儿具有低的峰值骨量,体重是最重要的影响因素,其次为母亲具低的BMD。
Objective To investigate if the peak bone mass of daughter with osteoporotic mother is lower than that of normal mother, and to explore the factors leading to this difference. METHODS: 401 Han Chinese nuclear families (including parents and a healthy daughter aged from 20 to 40 years) were recruited from various communities in Shanghai. Bone mineral density (BMD) in lumbar spine (L1-4) and proximal femur was measured by dual energy X-ray absorptiometry (BMD), excluding fathers with osteoporosis or osteopenia, received 126 osteoporosis mothers and their daughters and 136 age-matched normal BMD mothers and their daughters. Results The osteoporosis mother’s daughter L1-4, the femoral neck and the greater trochanter BMD (0.94g / cm2 ± 0.10g / cm2, 0.75g / cm2 ± 0.10g / cm2, 0.61g / cm2 ± 0.08g / cm2 (1.00g / cm2 ± 0.11g / cm2,0.80g / cm2 ± 0.11g / cm2,0.66g / cm2 ± 0.09g / cm2, all P <0.001), and the body weight was significantly lower There was no significant difference in the age, height, age of menarche, the proportion of milk intake, intake between the two groups in the normal mothers’ daughters (P <0.05) .Multiple factor stepwise regression analysis showed that: The most important factors in each part of BMD were 9.4%, 16.5% and 16.6% of L1-4, 16.5% and 16.6% of BMD variation in femoral neck and greater trochanter, respectively. Mothers with osteoporosis became the most important factor affecting their BMD , Respectively, to explain the differences in BMD of L1-4, femoral neck and greater trochanter were 5.1%, 5.3% and 4.2%, respectively.Conclusion Daughters with osteoporosis had low peak bone mass and body weight was the most important factor, followed by Low mothers BMD.