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用Ｗｉｓｔａｒ大鼠在氨基甲酸乙酯麻醉下研究微电泳５－羟色胺（５－ＨＴ）和５－ＨＴ４受体选择性激动剂灭吐灵对大脑皮质第一体感区（ＳＩ区）自发单位放电（ＳＩ－ＳＵＤ）和诱发单位放电（ＳＩ－ＥＵＤ）的影响。用计算机分别作放电间隔均值（ＩＳＩ）和标准化互协方差函数（ＮＣＣＶＦ）分析和统计学处理。结果表明：①５－ＨＴ对部分ＳＩ－ＳＵＤ单位有抑制或易化影响，其中５～２０ｎＡ时，只出现抑制影响；４０～１６０ｎＡ时有抑制或易化影响，抑制的例数较多。②微电泳５－ＨＴ５～２０ｎＡ时，对ＳＩ－ＥＵＤ单位无明显影响：４０～１６０ｎＡ时对部分ＳＩ－ＥＵＤ单位有抑制或易化的影响，抑制例数较多。③在５－ＨＴ抑制单位，单独或同时微电泳５－ＨＴ和灭吐灵均能抑制ＳＩ－ＳＵＤ和ＳＩ－ＥＵＤ，且给药组之间无显著性差异，提示５－ＨＴ４受体可能与５－ＨＴ抑制作用有关。
The spontaneous discharges of spontaneous units in the first somatosensory zone (SI) of the cerebral cortex were investigated using Wistar rats under urethane anesthesia (5-HT) and 5-HT4 receptor selective agonist metoclopramide SI-SUD) and induced unit discharge (SI-EUD). A computer was used to analyze and statistically calculate the mean discharge gap (ISI) and the standard mutual covariance function (NCCVF). The results showed that: (1) 5-HT had inhibitory or facilitation effect on some SI-SUD units, of which only inhibitory effect was observed at 5-20 nA, while inhibition or facilitation was observed at 40-160 nA, with a larger number of inhibitions. ② There was no significant effect on the SI-EUD units when 5-HT 5 ~ 20nA was applied in the microelectrophoresis. The inhibitory or facilitation effect on some SI-EUD units was observed when 40 ~ 160nA was applied. ③ In the 5-HT inhibition unit, SI-SUD and SI-EUD were both inhibited by 5-HT and metoclopramide alone or in combination with no significant difference between the two groups, suggesting that 5-HT4 receptor may be associated with 5-HT inhibition.