论文部分内容阅读
目的通过比较两种宫颈癌新辅助化疗方案的疗效及化疗不良反应,以期找到宫颈癌的最佳新辅助化疗方案。方法将68例Ib2～Ⅱb期宫颈癌患者术前随机分为A、B组,接受不同化疗方案化疗2个疗程。A组采用顺铂+多西他赛方案治疗30例,B组采用顺铂+阿霉素+氟尿嘧啶方案治疗38例。患者于化疗后2周左右行宫颈癌根治术。结果两种化疗方案总有效率为76.5%。两组患者在病灶缩小、症状缓解及不良反应方面比较差异均无统计学意义(P>0.05)。B组血清鳞状细胞癌抗原下降明显低于A组(P<0.05)。结论新辅助化疗能有效的控制宫颈局部病灶,顺铂+阿霉素+氟尿嘧啶是宫颈癌新辅助化疗较理想的方案。
Objective To compare the efficacy of two neoadjuvant chemotherapy regimens of cervical cancer and chemotherapy adverse reactions in order to find the best neoadjuvant chemotherapy regimen for cervical cancer. Methods Sixty-eight patients with stage2b-Ⅱb cervical cancer were randomly divided into two groups: group A and group B, receiving 2 courses of chemotherapy with different chemotherapy regimens. A group received cisplatin + docetaxel regimen in 30 cases, B group treated with cisplatin + doxorubicin + fluorouracil regimen in 38 cases. Patients underwent radical mastectomy for about 2 weeks after chemotherapy. Results The total effective rate of two chemotherapy regimens was 76.5%. There was no significant difference between the two groups in lesion reduction, symptom relief and adverse reactions (P> 0.05). The serum level of Squamous cell carcinoma antigen in group B was significantly lower than that in group A (P <0.05). Conclusion Neoadjuvant chemotherapy can effectively control cervical lesions, cisplatin + doxorubicin + fluorouracil neoadjuvant chemotherapy for cervical cancer is the ideal program.