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目的探讨卡维地洛对慢性充血性心力衰竭(CHF)患者心室重塑及心脏功能的影响。方法选择重症CHF患者43例,均接受常规CHF治疗(利尿剂、血管紧张素转换酶抑制剂),并随机分为治疗组和对照组。治疗组在常规CHF治疗的基础上加用卡维地洛。观察两组患者治疗前、治疗后6个月的左室舒张末内径(LVEDd)、左室收缩末内径(LVESd)、左室射血分数(LVEF)及心率、血压的变化。结果治疗6个月后,与对照组比较,治疗组心率减慢,LVEDd、LVESd、LVEF改善的程度更明显,差异有统计学意义。结论卡维地洛可显著逆转心室重塑,明显改善CHF患者心脏功能,疗效安全可靠。
Objective To investigate the effect of carvedilol on ventricular remodeling and cardiac function in patients with chronic congestive heart failure (CHF). Methods Forty-three patients with severe CHF were enrolled in this study. All patients received conventional CHF (diuretic and angiotensin converting enzyme inhibitor) and were randomly divided into treatment group and control group. The treatment group was given carvedilol on the basis of conventional CHF treatment. The changes of left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd), left ventricular ejection fraction (LVEF), heart rate and blood pressure before treatment and 6 months after treatment were observed in both groups. Results After 6 months of treatment, compared with the control group, the treatment group, heart rate slowed down, LVEDd, LVESd, LVEF improved more significantly, the difference was statistically significant. Conclusion Carvedilol can significantly reverse ventricular remodeling, significantly improve cardiac function in patients with CHF, safe and reliable.