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目的:探讨健脾益肾法对肿瘤放化疗白细胞减少症患者血清黏附分子ICAM-1、VCAM-1以及免疫功能的影响及其意义。方法:选取医院收治的肿瘤放化疗白细胞减少症患者81例,随机分为两组。对照组40例,行临床常规疗法治疗;实验组41例,在与对照组相同的临床常规治疗基础上加用健脾益肾方,比较两组患者血清ICAM-1、VCAM-1、免疫功能及治疗有效率。结果:治疗后与对照组相比,实验组血清ICAM-1、VCAM-1水平、外周血白细胞水平较高(P<0.05),实验组血清Ig A、Ig G、Ig M水平较高,血清Ig E水平较低(P<0.05),实验组CD~+3、CD~+4、CD~+4/CD~+8水平较高,血清CD~+8水平较低(P<0.05)。与对照组相比,实验组有效率较高(P<0.05)。结论:健脾益肾法对肿瘤放化疗白细胞减少症患者治疗据有较好的临床疗效,其可能机制为升高血清ICAM-1、VCAM-1水平,提高免疫功能及升高CD~+3、CD~+4细胞水平有关。
Objective: To investigate the effect of invigorating the spleen and invigorating the kidney on serum adhesion molecule ICAM-1, VCAM-1 and immune function in patients with tumor leukemia and chemotherapeutic leukopenia. Methods: Totally 81 patients with leukopenia who were admitted to hospital were randomly divided into two groups. Control group, 40 cases were treated with routine therapy. In the experimental group, 41 cases were treated with Jianpi Yishen Recipe based on the same routine treatment as the control group. The levels of serum ICAM-1, VCAM-1 and immune function were compared between the two groups And treatment efficiency. Results: Compared with the control group, the levels of serum ICAM-1, VCAM-1 and the level of peripheral leukocytes in the experimental group were significantly higher than those in the control group (P <0.05). The levels of serum IgA, IgG and IgM in the experimental group were higher than those in the control group (P <0.05). The level of CD ~ +3, CD ~ +4 and CD ~ +4 / CD ~ + 8 in the experimental group were higher than those in the experimental group. Compared with the control group, the experimental group was more efficient (P <0.05). Conclusion: The therapy of invigorating the spleen and invigorating the kidney method has good clinical curative effect in the treatment of patients with chemotherapy and leukopenia. The possible mechanism is to increase the level of serum ICAM-1 and VCAM-1, improve the immune function and raise the level of CD ~ + 3 , CD ~ + 4 cell level.