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目的:探讨结肠直肠癌肿瘤组织中P27kip1蛋白的表达情况与预后关系。方法:通过免疫组织化学染色法检测2002年12月至2004年12月于本院接受治疗的212位结肠直肠癌病人肿瘤组织标本中P27kip1蛋白的表达,同时对其中接受根治术的202例病人进行随访,分析P27kip1蛋白的表达与病人性别、年龄、肿瘤生长部位、大小、病理类型、分期及根治性手术后肿瘤发生转移、复发的关系。结果:212例结肠直肠肿瘤组织中P27kip1蛋白染色阳性表达者131例,占61.8%。P27kip1蛋白阳性表达与肿瘤直径呈负相关(P=0.045);P27kip1蛋白阳性表达程度的高低与肿瘤复发率、死亡率呈负相关(P<0.001)。右半结肠癌的P27kip1蛋白阳性表达与肿瘤淋巴转移情况呈负相关(P=0.003)。但P27kip1蛋白表达与病人性别、年龄、肿瘤生长部位、病理类型、分期及有无转移均无显著相关性(P>0.05)。结论:结肠直肠癌肿瘤组织中P27kip1蛋白的表达情况可以评估结肠直肠癌手术治疗的预后情况,具重要的临床参考价值。
Objective: To investigate the relationship between P27kip1 protein expression and prognosis in colorectal cancer. Methods: The expression of P27kip1 protein in 212 samples of colorectal cancer patients treated in our hospital from December 2002 to December 2004 was detected by immunohistochemical staining. Meanwhile, 202 patients undergoing radical operation The relationship between the expression of P27kip1 protein and the gender, age, site of tumor growth, size, pathological type, staging and tumor recurrence and metastasis after radical surgery were analyzed. Results: The positive expression of P27kip1 protein in 212 cases of colorectal tumor was 131 cases (61.8%). The positive expression of P27kip1 protein was negatively correlated with tumor diameter (P = 0.045). The positive expression of P27kip1 protein was negatively correlated with tumor recurrence rate and mortality (P <0.001). The positive expression of P27kip1 in right colon cancer was negatively correlated with lymph node metastasis (P = 0.003). However, P27kip1 protein expression had no significant correlation with patient’s gender, age, tumor’s growth location, pathological type, stage and metastasis (P> 0.05). Conclusion: The expression of P27kip1 protein in colorectal cancer tissue can evaluate the prognosis of colorectal cancer surgery, which has important clinical reference value.