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为探讨碱性纤维母细胞生长因子对急性心肌梗塞的影响及临床应用前景，用冠状动脉结扎法制备了家兔急性心肌梗塞模型．在此模型上亿脉注射碱性纤维母细胞生长因子1．4μg/kg，共6次．结果发现能明显缩小心肌梗塞范围，梗塞心肌重量占心脏重量百分比分别为8．1％±2．7％和8．2％±2．1％，对照组为16．5％±3．2％（P＜0．05）；增加心输出量和心肌收缩力（±LVdq／dtmax显著增加）；增加梗塞区心肌ATP贮备（2．9±0．4和3．2±0．3μmol／g，对照组为2．3±0．3μmol／g，P＜0．01）．结果提示，碱性纤维母细胞生长因子具有促进梗塞心肌愈合和改善心功能的作用，且这一作用明显优于临床上常用的扩血管药硝酸甘油。
In order to investigate the effect of basic fibroblast growth factor on acute myocardial infarction and its clinical application prospects, a rabbit model of acute myocardial infarction was prepared by coronary artery ligation. In this model, we injected basic fibroblast growth factor 1.4 μg / kg for 6 times. The results showed that myocardial infarction range can be significantly reduced, myocardial infarction weight percentage accounted for 8.1% ± 2.7% and 8.2% ± 2.1%, control group was 16.5% ± 3.2% (P <0.05); increased cardiac output and myocardial contractility (± LVdq / dtmax increased significantly); increased myocardial ATP reserve (2.9 ± 0.4 and 3.2 ± 0.3μmol / g, The control group was 2.3 ± 0.3μmol / g, P <0.01). The results suggest that basic fibroblast growth factor can promote myocardial infarction and improve cardiac function, and this effect is clearly superior to the commonly used vasodilators nitroglycerin.