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目的探讨妊娠期肝内胆汁淤积症的临床诊治方法。方法选取桂林市中西医结合医院2014年4月—2016年4月收治的妊娠期肝内胆汁淤积症孕产妇20例为观察组,选取本院同期非肝内胆汁淤积症孕产妇20例为对照组。对照组孕产妇给予常规对症治疗,观察组孕产妇给予丹参+黄芪+维生素C静脉滴注治疗,持续治疗1周。比较两组孕产妇血液生化指标[碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、总胆汁酸(TBA)、总胆红素(TBi Li)、直接胆红素(DBi Li)]及妊娠结局。结果观察组患者ALP、ALT、TBA、TBi Li、DBi Li水平高于对照组(P<0.05)。观察组产后出血发生率、早产率、剖宫产率、羊水污染发生率、胎儿窘迫发生率高于对照组(P<0.05)。结论妊娠期肝内胆汁淤积症严重危害着孕产妇和胎儿的生命安全,临床需给予及时诊断和治疗,改善妊娠结局。
Objective To investigate the clinical diagnosis and treatment of intrahepatic cholestasis of pregnancy. Methods 20 cases of pregnant women with intrahepatic cholestasis of pregnancy admitted from April 2014 to April 2016 in Guilin Integrative Medicine Hospital were selected as the observation group and 20 pregnant women with non-intrahepatic cholestasis in our hospital were selected as the control group. The control group of pregnant women given conventional symptomatic treatment, observation group pregnant women given Salvia + Astragalus + vitamin C intravenous infusion treatment, continuous treatment for 1 week. Blood biochemical parameters of ALP, ALT, TBA, TBi Li and DBi Li were compared between the two groups )] And pregnancy outcome. Results The levels of ALP, ALT, TBA, TBiLi and DBi Li in the observation group were significantly higher than those in the control group (P <0.05). The incidence of postpartum hemorrhage, preterm birth rate, cesarean section rate, incidence of amniotic fluid contamination and fetal distress in observation group were higher than those in control group (P <0.05). Conclusion Intrahepatic cholestasis of pregnancy seriously jeopardizes the lives and safety of pregnant women and fetuses. Clinically, they should be given timely diagnosis and treatment to improve the pregnancy outcome.