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0引言目前对肿瘤发病、转移、复发的研究主要在免疫机制等方面。肿瘤抗原免疫原性较弱以及存在肿瘤免疫逃逸问题是肿瘤免疫治疗效果尚不令人满意的原因。细胞免疫是抗肿瘤免疫的主力,在细胞免疫机制中起主要作用的效应细胞为T淋巴细胞等近年来,国内外掀起了对T-bet研究的热潮,已在胃
0 Introduction The current research on the incidence of cancer, metastasis, recurrence mainly in the immune mechanism and so on. The weak immunogenicity of tumor antigens and the existence of tumor immune escape are the reasons for the unsatisfactory effect of tumor immunotherapy. Cellular immunity is the mainstay of anti-tumor immunity, and the effector cells that play a major role in the cellular immune mechanism are T lymphocytes. In recent years, there has been a boom in T-bet research at home and abroad,