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目的考察灵雷菌质对佐剂型类风湿性关节炎(adjuvant arthritis,AA)大鼠的治疗作用。方法建立弗氏完全佐剂(Fre-und’s complete adjuvant,CFA)诱导的大鼠类风湿性关节炎(rheumatoid arthritis,RA)模型,将大鼠分为空白组、灵雷菌质高剂量给药组、灵雷菌质低剂量给药组、雷公藤多苷片给药组、模型组,连续灌胃给药2周后,检测各组大鼠的体重、关节肿胀度、关节炎指数、关节病理变化、血清肿瘤坏死因子(TNF)-α和白细胞介素(IL)-1β。结果灵雷菌质能改善大鼠一般状况并提高AA大鼠体重,缓解AA大鼠关节红肿程度,降低其关节炎指数,改善RA大鼠的关节病理变化,显著抑制TNF-α和IL-1β的表达。结论灵雷菌质对佐剂型关节炎有一定的治疗作用。
Objective To investigate the therapeutic effect of Lingrui on the adjuvant arthritis (AA) rats. Methods A rat model of rheumatoid arthritis (RA) induced by Freund’s complete adjuvant (CFA) was established. The rats were divided into blank group, high dose Lingling bacilli administration group , Low dose Lingling bacilli administration group, tripterygium glycosides tablets administration group and model group. After two weeks’ administration, the body weight, joint swelling, arthritis index, joint pathology Changes, serum tumor necrosis factor (TNF) -alpha and interleukin (IL) -1β. Results Rhizopus oryzae could improve the general condition of rats and increase the body weight of AA rats, relieve the degree of joint swelling in AA rats, reduce the arthritis index, improve the pathological changes of joints in RA rats and significantly inhibit the expression of TNF-α and IL-1β expression. Conclusions Lingrui mushroom has certain therapeutic effect on adjuvant arthritis.