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嗅神经母细胞瘤是一种少见的肿瘤,约占鼻腔恶性肿瘤的1～5％。Berger 1924年首次报道本病以来又有约300例报告。根据这些报告,此肿瘤可来源于蝶腭神经节,犁鼻器官嗅粘膜的神经上皮细胞等部位。1976年Kadish根据疾病的范围分为A期(病变局限于鼻腔);B期(病变局限于鼻腔及鼻窦);C期(病变超过鼻腔及鼻窦范围,累及到眼眶、颅内、颈淋巴结或有远部位的转移)。1990年Biller等根据肿瘤的TNM分类模式提出新的分类方法,T_1:肿瘤累及鼻腔和邻近的鼻窦(除外蝶窦),可伴有前颅窝的骨质破坏。T_2:肿瘤
Olfactory neuroblastoma is a rare tumor, accounting for about 1 to 5% of nasal malignancies. Since Berger first reported this disease in 1924, about 300 more reports have been reported. According to these reports, the tumor can be derived from the sphenopalatine ganglion, the pterygium nasal mucosa, epithelial cells and other parts of the olfactory epithelium. In 1976 Kadish according to the scope of the disease is divided into A period (lesions limited to the nasal cavity); B (lesions limited to the nasal and sinus); C (lesions beyond the scope of the nasal and sinus, involving the orbit, intracranial, cervical lymph nodes or Far-site transfer). In 1990, Biller et al. Proposed a new classification method based on TNM classification of tumors. T_1: The tumor involved the nasal cavity and adjacent sinuses (except the sphenoid sinus), which may be associated with bone destruction of the anterior cranial fossa. T_2: tumor