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AIM:To investigate the expression of programmed cell death 4(Pdcd4)tumor suppressor gene in tissue specimen of renal cell carcinoma(RCC),testicular germ cell cancer and penile cancer.METHODS:Pdcd4 expression was studied using immunohistochemistry in 188 cases of RCC and 28 controls(including 9 oncocytoma);in 74 cases of penile carcinoma(including 17 metastatic tissue samples)and26 controls;in 11 cases of seminoma,in 14 cases of non-seminoma and 5 controls.RESULTS:Control tissues exhibited strong core and cytoplasmatic Pdcd4 staining.In contrast,core and cy-toplasmatic Pdcd4 levels were significantly decreased in cancer tissues.CONCLUSION:Our data support a role for Pdcd4(down-)regulation in urologic tumors.Interestingly,Pdcd4 expression seem to be a potential diagnostic marker for renal or penile tumors.
AIM: To investigate the expression of programmed cell death 4 (Pdcd4) tumor suppressor gene in tissue specimen of renal cell carcinoma (RCC), testicular germ cell cancer and penile cancer. METHODS: Pdcd4 expression was studied using immunohistochemistry in 188 cases of RCC and 28 controls (including 9 oncocytoma); in 74 cases of penile carcinoma (including 17 metastatic tissue samples) and 26 controls; in 11 cases of seminoma, in 14 cases of non-seminoma and 5 controls .RESULTS: Control of tissues with strong core and cytoplasmatic Pdcd4 staining. Core, and cy-toplasmatic Pdcd4 levels were significantly decreased in cancer tissues. CONCLUSION: Our data support a role for Pdcd4 (down-) regulation in urologic tumors. Interestingly, Pdcd4 expression seem to be a potential diagnostic marker for renal or penile tumors.