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正常狗灌胃海州常山叶水煎剂1次20g/kg以上即嘔吐,10g/kg以下无嘔吐。每天灌胃10g/kg,共3周,肝机能、血象、心电图及病理检查均无明显改变。慢性腎型高血压狗5只,听诊测量颈动脉皮桥血压。每日灌胃10g/kg,共4周。在给药第2周降压作用开始显著,继续给药则降压更多。每周平均舒张压低时分别下降32,17,6,20,12mmHg(25％,14％,5％,16％,10％)。心搏率、肝机能及血象无明显变化、给药第3周以后3只狗心电图T波变为倒置。与本实验室过去以慢性腎型高血压狗口服几种中药相比较,海州常山比藜芦、黄芩及蘿芙木全硷的降压效力可能稍差,与二仙合剂相差不多,但比杜仲较好。
Normal dog gavage Haizhou Changshan leaf decoction once 20g / kg or more vomiting, 10g / kg the following no vomiting. Gavage 10g / kg daily for 3 weeks, liver function, blood, ECG and pathological examination showed no significant change. Chronic renal hypertensive dogs 5, auscultatory measurement of carotid artery skin graft pressure. Daily gavage 10g / kg, a total of 4 weeks. Antihypertensive effect started significantly at the second week of administration, and the antihypertensive effect was more after continued administration. Weekly average diastolic blood pressure decreased by 32,17,6,20,12 mmHg (25%, 14%, 5%, 16%, 10%). Heart rate, liver function and blood no significant change in the third week after administration of three dogs ECG T wave into an inverted. Compared with the oral administration of several traditional Chinese medicines to chronic renal hypertension dogs in this laboratory in the past, the antihypertensive efficacy of Haizhou Changshan than Veratrum, Scutellaria baicalensis and Rauvolfia total alkaloids may be somewhat inferior, which is similar to that of Erxian mixture, Eucommia better.