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紫杉醇对非小细胞肺癌有较高的疗效,然而紫杉醇溶媒中聚氧乙基蓖麻油在体内降解时释放组胺所产生的变态反应限制了它的使用,而紫杉醇脂质体避免了它的变态反应,且有一定的靶向性,提高了疗效,减轻了毒性。我院自2008年5月至2009年6月应用周剂量紫杉醇脂质体联合图像引导放射治疗70岁以上老年非小细胞肺癌患者24例,观察近期疗效和毒副反应、生活质量和1年的生存率,现报告如下。
Paclitaxel has a high efficacy in non-small cell lung cancer, whereas the allergy caused by the release of histamine from polyoxyethylene castor oil in paclitaxel vehicle limits its use, whereas paclitaxel liposomes avoid its metamorphosis Reaction, and have a certain degree of targeting, improve the curative effect, reduce the toxicity. In our hospital from May 2008 to June 2009 weekly dose paclitaxel liposome combined with guided radiotherapy in patients over the age of 70 elderly patients with non-small cell lung cancer in 24 cases, to observe the short-term efficacy and adverse reactions, quality of life and 1 year Survival rate, the report is as follows now.