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2.8稳定动脉斑块血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)可以刺激内皮素释放。内皮素是一种最强的冠状动脉收缩因子,在冠状动脉易损斑块存在的前提下,内皮素的释放可能会导致斑块破裂。低镁血症能引起冠状动脉血管反应性增加,促进斑块破裂。AngⅡ能够导致与镁缺乏相关的多种变化,包括诱导促氧化剂和促炎因子的生成。而且,AngⅡ能诱导内皮细胞合成纤溶酶原激活物抑制因子1。因此,激活肾素血管紧张素系统(renin-
2.8 stable arterial plaque angiotensin Ⅱ (angiotensin Ⅱ, Ang Ⅱ) can stimulate the release of endothelin. Endothelin is one of the strongest coronary contractile factors, and the release of endothelin may cause plaque rupture in the presence of vulnerable plaque in the coronary artery. Hypomagnesemia can cause increased coronary vascular reactivity and promote plaque rupture. Ang II can lead to a variety of changes associated with magnesium deficiency, including the induction of pro-oxidants and proinflammatory cytokines. Moreover, Ang II induces the synthesis of plasminogen activator inhibitor 1 by endothelial cells. Therefore, activation of the renin-