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目的探讨纤维蛋白原和血常规检测对乙型肝炎的诊断价值。方法选取2012年3月—2014年12月义马市义煤集团总医院收治的乙型肝炎患者160例和同期体检健康者30例。根据病情分为急性乙型肝炎组(60例)、慢性乙型肝炎组(60例)、重症乙型肝炎组(20例)、肝硬化组(20例),体检健康者为对照组。比较5组研究对象纤维蛋白各项指标〔纤维蛋白单体聚合反应速率(FMPS),纤维蛋白原含量(FC),最大吸光度(A-max),纤维蛋白原功能指数(FI),反应延滞时间(DT)〕、常规各项指标〔平均红细胞体积(MCV),红细胞分布宽度(RDW),血小板体积分布宽度(PDW),平均血小板体积(MPV)〕。结果慢性乙型肝炎组、重症乙型肝炎组、肝硬化组纤维蛋白原各项指标低于对照组,差异有统计学意义(P<0.05)。慢性乙型肝炎组、重症乙型肝炎组、肝硬化组RDW高于对照组,慢性乙型肝炎组、肝硬化组MCV大于对照组,差异有统计学意义(P<0.05)。急性乙型肝炎组与对照组MCV比较,差异无统计学意义(P>0.05)。结论纤维蛋白原和血常规指标可反映乙型肝炎患者肝脏病变程度,具有一定的诊断价值。
Objective To investigate the diagnostic value of fibrinogen and blood routine test in hepatitis B patients. Methods From March 2012 to December 2014, 160 cases of hepatitis B patients and 30 healthy subjects were enrolled in YICC General Yichang General Hospital. The patients were divided into acute hepatitis B group (60 cases), chronic hepatitis B group (60 cases), severe hepatitis B group (20 cases), cirrhosis group (20 cases) and healthy control group as the control group. The indexes of fibrin, such as fibrin monomer polymerization rate (FMPS), fibrinogen content (FC), maximum absorbance (A-max), fibrinogen function index (FI), reaction delay time (DT)], routine indicators (average red blood cell volume (MCV), red blood cell distribution width (RDW), platelet volume distribution width (PDW), average platelet volume (MPV)]. Results The indexes of fibrinogen in chronic hepatitis B group, severe hepatitis B group and cirrhosis group were lower than those in control group, with statistical significance (P <0.05). The RDW in chronic hepatitis B group, severe hepatitis B group and cirrhosis group were higher than those in control group. The MCV in chronic hepatitis B group and cirrhosis group was higher than that in control group (P <0.05). There was no significant difference in MCV between acute hepatitis B group and control group (P> 0.05). Conclusion Fibrinogen and blood indexes can reflect the degree of hepatic lesion in patients with hepatitis B, and have certain diagnostic value.