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目的:观察磺脲类药物继发性失效者联合甘精胰岛素治疗2型糖尿病的疗效及胰岛β细胞功能变化。方法:对磺脲类药物继发性失效患者改用格列美脲,睡前分别注射甘精胰岛素(甘精组,24例)、优泌林30R(优泌林组,30例),12周后比较两组血糖、糖化血红蛋白(HbA1c)以及血清C肽的变化。结果:两组血糖和HbA1c均有下降(P<0.01或P<0.05),治疗后C肽升高(P<0.05)。结论:联合甘精胰岛素治疗2型糖尿病有较好疗效,并有可能改善β细胞的功能。
Objective: To observe the efficacy of sulfonylurea secondary failure combined with insulin glargine in the treatment of type 2 diabetes mellitus and changes of pancreatic β-cell function. Methods: The patients with secondary failure of sulfonylurea were switched to glimepiride, and insulin glargine (24 cases in Gan Gan Jing group), 30R (30 cases in superior gum group), 12 cases The changes of blood glucose, glycosylated hemoglobin (HbA1c) and serum C-peptide were compared between the two groups afterwards. Results: The levels of blood glucose and HbA1c in both groups decreased (P <0.01 or P <0.05), and C peptide increased after treatment (P <0.05). CONCLUSION: Combination of insulin glargine with type 2 diabetes has a good effect and may improve the function of β cells.