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帕金森病是常见神经系统变性疾病,以中脑黑质多巴胺(DA)神经元变性坏死和患者脑内出现Lewy小体为主要病理特点。神经元缺失的同时伴胶质细胞反应,尤其是小胶质细胞激活,近年来诸多证据显示小胶质细胞激活可以介导活性氧产物,致炎性细胞因子、一氧化氮等相关产物的神经毒性作用,干预小胶质细胞激活有助于阻止PD进程。本文综述小胶质细胞在PD中的神经破坏作用以及目前药物干预治疗的进展。
Parkinson’s disease is a common degenerative disease of the nervous system. The degeneration and necrosis of dopamine (DA) neurons in the substantia nigra and the presence of Lewy bodies in the brain are the main pathological features. Neuronal loss accompanied by glial cells, especially microglial activation, in recent years a lot of evidence that microglial activation can be mediated by reactive oxygen species, proinflammatory cytokines, nitric oxide and other related products of nerve Toxicity, intervention in microglia activation helps stop the PD process. This article reviews the role of microglia in neurodegeneration in PD as well as the current advances in drug interventions.