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目的：评估视觉发育关键期单眼眼睑缝合对视觉诱发电位的影响．方法：应用ＰａｔｈｆｉｎｄｅｒⅡ型视觉诱发电位仪记录正常（１５只）和单眼剥夺（１８只）猫生后７～８，１１～１２和１５～１６周龄的图形视觉诱发电位（ＰＶＥＰ）．结果：正常眼（ＮＥ）随视觉发育Ｎ１－Ｐ１波幅值逐渐增大，Ｐ１潜伏期值缩短．剥夺眼（ＤＥ）的Ｎ１－Ｐ１波幅值减少，ＮＥ／ＤＥ在ＰＮＷ７～８（Ｐ＜０．０５），ＰＮＷ１５～１６（Ｐ＜０．０１）；而Ｐ１潜伏期值延迟，ＮＥ／ＤＥ在ＰＮＷ７～８（Ｐ＞０．０５），ＰＮＷ１５～１６（Ｐ＜０．０５）．结论：单眼剥夺可造成剥夺眼Ｎ１－Ｐ１波幅降低，Ｐ１潜时延长，剥夺时间越长，损害越严重．Ｎ１－Ｐ１波幅较Ｐ１潜时对单眼剥夺造成的损害更敏感．
Objective: To evaluate the effect of single eyelid suture on visual evoked potentials during the critical period of visual development. Methods: The visual evoked potentials (PVEP) of 7, 8, 11 ~ 12 and 15 ~ 16 weeks after cats were recorded by Pathfinder Ⅱ visual evoked potential meter in normal (15) and monocular deprived (18) cats. Results: The amplitude of N1-P1 in normal eyes (NE) gradually increased with the visual development, and the latency of P1 shortened. The amplitude of N1-P1 in deprived eyes (DE) decreased, while NE / DE was in PNW7-8 (P <0.05) and PNW15-16 (P <0.01) PNW7 ~ 8 (P> 0.05), PNW15 ~ 16 (P <0.05). CONCLUSION: Monocular deprivation can reduce the amplitude of N1-P1 in deprived eyes and prolong the latent period of P1. The longer the deprivation period, the more serious the damage. N1-P1 amplitude is more sensitive to damage caused by monocular deprivation than P1 latency.