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目的:探讨晚期早产儿颅内出血的相关因素,指导晚期早产儿颅内出血的防治。方法:2011年9月至2012年8月我院收治晚期早产儿253例,其中有210例行头颅MRI检查,以经头颅MRI检查确诊颅内出血30例为ICH组,同时随机抽取同期住院的经头颅MRI证实无颅内出血晚期早产儿60例作为对照组。应用SPSS 17.0进行统计学分析。结果:1.ICH组产前激素应用率显著低于对照组(P<0.05)。2.ICH组经阴分娩、胎膜早破、代谢性酸中毒发生率显著高于对照组(P<0.05)。3.Logistic回归分析显示产前激素是颅内出血的保护因素(P<0.05),而经阴分娩、胎膜早破(P<0.01)、代谢性酸中毒(P<0.05)是颅内出血的危险因素。结论:产前应用激素是晚期早产儿颅内出血的保护因素,经阴分娩、胎膜早破、代谢性酸中毒是晚期早产儿颅内出血高危因素。
Objective: To explore the related factors of intracranial hemorrhage in late preterm children and to guide the prevention and treatment of intracranial hemorrhage in premature infants. Methods: From September 2011 to August 2012, 253 cases of advanced preterm infants were admitted to our hospital. Among them, 210 cases were examined by cranial MRI, 30 cases were diagnosed intracranial hemorrhage by cranial MRI as ICH group, Head MRI confirmed that 60 cases of advanced preterm children without intracranial hemorrhage as a control group. SPSS 17.0 was used for statistical analysis. Results: 1. The rate of prenatal hormone application in the IH group was significantly lower than that in the control group (P <0.05). The incidence of vaginal delivery, premature rupture of membranes and metabolic acidosis in the HI group were significantly higher than those in the control group (P <0.05). Logistic regression analysis showed that prenatal hormones were the protective factors of intracranial hemorrhage (P <0.05), while those of vaginal delivery and premature rupture of membranes (P <0.01) and metabolic acidosis (P <0.05) were the risk of intracranial hemorrhage factor. Conclusion: Prenatal hormones are the protective factors of intracranial hemorrhage in premature infants with late preterm birth. The risk factors for intracranial hemorrhage in preterm infants with late preterm birth are vaginal delivery, premature rupture of membranes and metabolic acidosis.