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在糖尿病的患者,如果不合并冠心病心肌缺血,基本均处于亚临床状态的心肌损害,心功能表现为早期舒张功能不全以及晚期合并收缩功能不全,其机制是心肌能量代谢的异常导致一系列的病理生理学改变,包括糖类代谢紊乱、脂肪酸的氧化和心肌脂质聚集等,也就是目前常说的糖尿病心肌病。对于严重的糖尿病患者如果遭遇心肌缺血的打击,其更加容易发生心力衰竭和死亡,拥有明显更差的预后,其机制是什么呢?现将详细加以阐述。
In patients with diabetes, myocardial infarction without coronary heart disease, are basically in subclinical myocardial damage, cardiac function as early diastolic dysfunction and late systolic dysfunction, the mechanism is the abnormal myocardial energy metabolism led to a series of Pathophysiological changes, including the metabolism of carbohydrates, fatty acid oxidation and myocardial lipid accumulation, which is often said that diabetic cardiomyopathy. For serious diabetic patients suffering from myocardial ischemia hit, it is more prone to heart failure and death, has a significantly worse prognosis, the mechanism is what? Now elaborate.