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目的 :观察盐酸氮 艹卓 斯汀 (AzelastineHydrochloride ,AZ)对豚鼠实验性哮喘的作用、药效学及药动学特点及作用机制。方法 :采用组胺和乙酰胆碱诱发在体豚鼠实验性哮喘模型。结果 :盐酸氮 艹卓 斯汀能够剂量依赖性地拮抗组胺和乙酰胆碱的引喘作用 ,明显延长引喘潜伏期 ,显著减少抽搐动物发生率 ,其ED50 为 0 .2 1 6mg/kg ,95 %可信限为 0 .2 1 4～ 0 .2 1 9mg/kg。结论 :预先给予盐酸氮 艹卓 斯汀能显著拮抗组胺和乙酰胆碱所诱发的在体豚鼠实验性哮喘。
Objective: To observe the effects of aztreonin hydrochloride (AZ) on experimental asthma in guinea pigs, pharmacodynamics and pharmacokinetics and its mechanism. Methods: Histamine and acetylcholine were used to induce experimental asthma in guinea pigs. Results: Nitazoxanide could antagonize the asthmatic effect of histamine and acetylcholine in a dose-dependent manner, prolong the latent period of asthma and significantly reduce the incidence of convulsions. The ED50 was 0.226mg / kg, 95% The letter of credit is 0 .2 1 4 ~ 0 .2 1 9mg / kg. CONCLUSION: Pretreatment with aztreonam hydrochloride significantly inhibits histamine and acetylcholine-induced experimental asthma in guinea pigs.