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目的探讨Wernicke脑病的临床、影像学特点。资料与方法回顾性分析4例Wernicke脑病患者的临床、影像学资料。结果4例均非酒精中毒患者,临床均有不同程度精神、意识障碍,发病前3例有不同程度的恶心、呕吐,眼肌麻痹2例,4例均行MRI头颅扫描,3例首诊阳性,1例首检漏诊,复查发现。MRI均表现为第三、四脑室及中脑导水管周围对称性的长T1、长T2异常信号。2例经维生素B1治疗明显好转,1例死亡。结论Wernicke脑病临床表现常不典型,MRI检查可为Wernicke脑病的早期诊断提供帮助,及早治疗、预后较好。
Objective To investigate the clinical and imaging features of Wernicke encephalopathy. Materials and Methods Clinical and imaging data of 4 patients with Wernicke encephalopathy were retrospectively analyzed. Results All 4 patients were non-alcoholic. All patients had different degrees of psychosis and disturbance of consciousness. There were 2 cases of nausea, vomiting and ophthalmoplegia in 3 cases before the onset. MRI scans were performed in 4 cases and positive in 3 cases , A case of first missed diagnosis, review found. MRI showed the third, fourth ventricle and midbrain symmetry around the aqueduct of long T1, T2 abnormal signal. Two cases of treatment by vitamin B1 improved significantly, 1 patient died. Conclusion The clinical manifestations of Wernicke’s encephalopathy are often not typical. MRI can provide early diagnosis for Wernicke’s encephalopathy. Early treatment and better prognosis.