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目的:探讨进展期胃癌术中行区域性缓释化疗的安全性。方法:选取我院2009年1月~2012年12月84例进展期胃癌患者,按照患者意愿将其分成研究组和对照组,研究组患者予以区域性缓释化疗,对照组单纯应用常规性治疗,分析2组患者治疗效果和近期、远期疗效。结果:研究组患者腹腔引流液量和引流管留置时间增加,差异明显;2组第1年生存率无差异性,2、3年生存率差异性明显,具有统计学意义(P<0.05)。结论:区域性缓释化疗可以及时消除癌细胞,降低复发率,增加患者生命,局部应用具有较高安全性,且为增加并发症发生率,在进展期胃癌术实施具有良好的安全性、可靠性,简单方便,效果显著,临床推广应用价值高。
Objective: To investigate the safety of regional delayed-release chemotherapy in advanced gastric cancer. Methods: Eighty-four patients with advanced gastric cancer from January 2009 to December 2012 in our hospital were divided into study group and control group according to patients’ wishes. Patients in study group were treated with regional sustained-release chemotherapy while those in control group were treated with conventional therapy , Analysis of two groups of patients with treatment and short-term, long-term efficacy. Results: The peritoneal drainage volume and drainage tube indwelling time of the study group increased significantly with significant difference. There was no difference in the 1-year survival rate and significant difference in the 2-year and 3-year survival rates between the two groups (P <0.05). Conclusion: The regional delayed-release chemotherapy can promptly eliminate cancer cells, reduce the recurrence rate and increase the patient’s life. Local application has high safety. In order to increase the incidence of complications, advanced gastric cancer surgery has good safety and reliability Sex, simple and convenient, the effect is significant, clinical application of high value.