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目的探讨CD44v6和P16表达与子宫内膜腺癌生物学行为的关系。方法应用免疫组化方法,对50例原发性子宫内膜腺癌组织进行了CD44v6和P16检测。结果CD44v6和P16在子宫内膜腺癌中阳性率分别为70%和52%。CD44v6和P16表达与子宫内膜腺癌的组织学分级、临床分期和转移相关(P<0.05)。结论CD44v6和P16表达可作为判断子宫内膜腺癌的恶性程度、预测肿瘤侵袭转移和评估预后的参考指标。
Objective To investigate the relationship between the expression of CD44v6 and P16 and the biological behavior of endometrial adenocarcinoma. Methods Immunohistochemistry was used to detect CD44v6 and P16 in 50 cases of primary endometrial adenocarcinoma. Results The positive rates of CD44v6 and P16 in endometrial adenocarcinoma were 70% and 52% respectively. The expression of CD44v6 and P16 were correlated with histological grade, clinical stage and metastasis of endometrial adenocarcinoma (P <0.05). Conclusion The expression of CD44v6 and P16 may be used as a reference to judge the malignant degree of endometrial adenocarcinoma and predict the tumor invasion and metastasis and to evaluate the prognosis.