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  5. Potential application of FoldX force field based protein modeling in zinc finger nucleases design

Potential application of FoldX force field based protein modeling in zinc finger nucleases design

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：xll526
【摘 要】
：
Engineered sequence-specific zinc finger nucleases (ZFNs) make the highly efficient modification of eukaryotic genomes possible.However,most current strategies
【作 者】
：
HE ZuYong MEI Gui ZHAO ChunPen 
【机 构】
：
SlateKeyLaboratoryofBiocontrol,InstituteofAnimalSciences,CollegeofAnimalScienceandTechnology
【出 处】
：
中国科学：生命科学英文版
【发表日期】
：
2011年5期
【关键词】
：
计算辅助设计 锌指蛋白 核酸酶 力场 建模 序列特异性 应用 线性回归分析 zinc finger nuclease  FoldX  force field 
【基金项目】
：
This work was supported by the National Natural Science Foundation of China （Grant No. 30901018） and the China Postdoctoral Science Foundation （Grant No. 201003388）.
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Engineered sequence-specific zinc finger nucleases (ZFNs) make the highly efficient modification of eukaryotic genomes possible.However,most current strategies for developing zinc finger nucleases with customized sequence specificities require the constru
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